CONCLUSIONS: Our preliminary data demonstrate that ozone therapy is a valid supportive therapy for fatigue in cancer patients, both during cancer therapy and in a palliative setting with no significant side effects.

Mohamad Ali Dayani1ID, Ali Hasanpour Dehkordi2*ID, Maryam Miraghajani3,4 ID 1Department of Radiology, Shahrekord University of Medical Sciences, Shahrekord, Iran 2Social Determinants of Health Research Center.,School of allied medical scinces, Shahrekord University of Medical Sciences, Shahrekord, Iran 3Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

A B S T R A C TNitric oxide (NO) has various physiological and biochemical effects. In many biological systems of the body, NO acts as a messenger molecule via cyclic guanosine monophosphate (cGMP), which affects the body cells. NO is synthesized in the body from the L-arginine amino acid by the NO synthases enzyme. This enzyme consists of three major isoforms including neurotransmitter, endothelial and inductive types. According to the results of numerous studies, the administration of ozone as a complementary therapy of the diseases is a less complicated and cost-effective way. Over the past forty years, the results of ozone therapy have been satisfactory and without any problems. Ozone therapy affects various diseases. For example, in treatment for vascular diseases and some degenerative diseases, it has an ameliorative impact. Regarding kidney disease, still many experimental or clinical studies are necessary to find its improvement/anti-oxidative effect.

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